Toward enhanced hyperforin production in St. John's wort root cultures
نویسندگان
چکیده
منابع مشابه
Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.
BACKGROUND AND PURPOSE St. John's wort is a commonly used herbal medication that increases cytochrome P450 3A (CYP3A) activity. Because docetaxel is inactivated by CYP3A, we studied the effects of the St. John's wort constituent hyperforin on docetaxel metabolism in a human hepatocyte model. EXPERIMENTAL DESIGN Hepatocytes, isolated from three donor livers, were exposed to hyperforin (0.1, 0....
متن کاملInduction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
St. John's wort extract (SJW) (Hypericum perforatum L.) is among the most commonly used herbal medications in the United States. The predominance of clinical reports indicates that SJW increases the activity of cytochrome P450 3A4 (CYP3A4) enzyme and reduces plasma concentrations of certain drugs. Although the inductive effect of SJW on CYP3A4 is clear, other reports indicate that SJW constitue...
متن کاملNMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.
Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of affective disorders. Hyperforin, a constituent of St. John's wort, is known to modulate the release and re-uptake of various neurotransmitters, an action that likely underlies its antidepressive activity. We now report that hyperforin also has N-methyl-D-aspartate (NMDA)-antagonistic effe...
متن کاملRole of hyperforin in the pharmacological activities of St. John's Wort.
The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum. Experimental studies clearly demonstrated its activity in different behavioral models of depression. Moreover clinical studies linked the therapeutic efficacy of Hypericum extracts to their hyperforin content, in a dose-dependent manner. The molecular m...
متن کاملHyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels.
Hyperforin, a bicyclic polyprenylated acylphloroglucinol derivative, is the main active principle of St. John's wort extract responsible for its antidepressive profile. Hyperforin inhibits the neuronal serotonin and norepinephrine uptake comparable to synthetic antidepressants. In contrast to synthetic antidepressants directly blocking neuronal amine uptake, hyperforin increases synaptic seroto...
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ژورنال
عنوان ژورنال: Engineering in Life Sciences
سال: 2019
ISSN: 1618-0240,1618-2863
DOI: 10.1002/elsc.201900043